Mtbook, the M. tuberculosis genome in a book

Rv2839c

2700 bp reverse orf at [08:33]

-> Mtbook page 971

infB

initiation factor IF-2

Function

Classification II. A.6
Category II. Macromolecule metabolism
Class A. Synthesis and modification of macromolecules
Group 6. Protein translation and modification

Protein

900 aminoacids, 94 kDa

>Rv2839c VAAGKARVHELAKELGVTSKEVLARLSEQGEFVKSASSTVEAPVARRLRESFGGSKPAPAKGTAKSPGKGPDKSLDKALDAAIDMAAGNGKATAAPAKAADSGGAAIVSPTTPAAPEPPTAVPPSPQAPHPGMAPGARPGPVPKPGIRTPRVGNNPFSSAQPADRPIPRPPAPRPGTARPGVPRPGASPGSMPPRPGGAVGGARPPRPGAPRPGGRPGAPGAGRSDAGGGNYRGGGVGAAPGTGFRGRPGGGGGGRPGQRGGAAGAFGRPGGAPRRGRKSKRQKRQEYDSMQAPVVGGVRLPHGNGETIRLARGASLSDFADKIDANPAALVQALFNLGEMVTATQSVGDETLELLGSEMNYNVQVVSPEDEDRELLESFDLSYGEDEGGEEDLQVRPPVVTVMGHVDHGKTRLLDTIRKANVREAEAGGITQHIGAYQVAVDLDGSQRLITFIDTPGHEAFTAMRARGAKATDIAILVVAADDGVMPQTVEAINHAQAADVPIVVAVNKIDKEGADPAKIRGQLTEYGLVPEEFGGDTMFVDISAKQGTNIEALEEAVLLTADAALDLRANPDMEAQGVAIEAHLDRGRGPVATVLVQRGTLRVGDSVVAGDAYGRVRRMVDEHGEDVEVALPSRPVQVIGFTSVPGAGDNFLVVDEDRIARQIADRRSARKRNALAARSRKRISLEDLDSALKETSQLNLILKGDNAGTVEALEEALMGIQVDDEVVLRVIDRGVGGITETNVNLASASDAVIIGFNVRAEGKATELASREGVEIRYYSVIYQAIDEIEQALRGLLKPIYEENQLGRAEIRALFRSSKVGLIAGCLVTSGVMRRNAKARLLRDNIVVAENLSIASLRREKDDVTEVRDGFECGLTLGYADIKEGDVIESYELVQKERA*

Pedant links: Pedant report, prosite patterns,
intragenome comparison,
blastp homologues

Lookup

PubMed: infB, infB and M. tuberculosis,
initiation factor IF-2,
Sanger Rv2839c, Tigr MT2905

Rv2841c

1041 bp reverse orf at [08:33]

-> Mtbook page 972

nusA

transcription termination factor

Function

Classification II. A.7
Category II. Macromolecule metabolism
Class A. Synthesis and modification of macromolecules
Group 7. RNA synthesis, RNA modification and DNA transcription

Protein

347 aminoacids, 37,6 kDa

>Rv2841c MNIDMAALHAIEVDRGISVNELLETIKSALLTAYRHTQGHQTDARIEIDRKTGVVRVIARETDEAGNLISEWDDTPEGFGRIAATTARQVMLQRFRDAENERTYGEFSTREGEIVAGVIQRDSRANARGLVVVRIGTETKASEGVIPAAEQVPGESYEHGNRLRCYVVGVTRGAREPLITLSRTHPNLVRKLFSLEVPEIADGSVEIVAVAREAGHRSKIAVRSNVAGLNAKGACIGPMGQRVRNVMSELSGEKIDIIDYDDDPARFVANALSPAKVVSVSVIDQTARAARVVVPDFQLSLAIGKEGQNARLAARLTGWRIDIRGDAPPPPPGQPEPGVSRGMAHDR*

Pedant links: Pedant report, prosite patterns,
intragenome comparison,
blastp homologues

Lookup

PubMed: nusA, nusA and M. tuberculosis,
transcription termination factor,
Sanger Rv2841c, Tigr MT2907

Rv2845c

1746 bp reverse orf at [08:34]

-> Mtbook page 973

proS

prolyl-tRNA synthase

Function

Classification II. A.3
Category II. Macromolecule metabolism
Class A. Synthesis and modification of macromolecules
Group 3. Aminoacyl tRNA synthases and their modification

Protein

582 aminoacids, 63,3 kDa

>Rv2845c VITRMSELFLRTLRDDPADAEVASHKLLIRAGYIRPVAPGLYSWLPLGLRVLRNIERVIRDEMNAIGGQEILFPALLPRAPYETTNRWTQYGDSVFRLKDRRGNDYLLGPTHEELFTLTVKGEYSSYKDFPLTLYQIQTKYRDEARPRAGILRAREFVMKDSYSFDIDAAGLKAAYHAHREAYQRIFDRLQVRYVIVSAVSGAMGGSASEEFLAESPSGEDAFVRCLESGYAANVEAVVTARPDTLPIDGLPEAVVHDTGDTPTIASLVAWANEADLGRTVTAADTLKNVLIKVRQPGGDTELLAIGVPGDREVDDKRLGAALEPADYALLDDDDFAKHPFLVKGYIGPKALRENNVRYLVDPRIVDGTSWITGADQPGRHVVGLVAGRDFTADGTIEAAEVREGDPSPDGAGPLVMARGIEIGHIFQLGSKYTDAFTADVLGEDGKPVRLTMGSYGIGVSRLVAVVAEQHHDELGLRWPSTVAPFDVHLVIANKDAQARAGATALAADLDRLGVEVLLDDRQASPGVKFKDAELLGMPWIVVVGRGWADGVVELRDRFSGQTRELVAGASLATDIAAAVTG*

Pedant links: Pedant report, prosite patterns,
intragenome comparison,
blastp homologues

Lookup

PubMed: proS, proS and M. tuberculosis,
prolyl-tRNA synthase,
Sanger Rv2845c, Tigr MT2911

Rv2846c

1590 bp reverse orf at [08:34]

-> Mtbook page 974

efpA

putative efflux protein

Function

Classification III. A.6
Category III. Cell processes
Class A. Transport/binding proteins
Group 6. Efflux proteins

Protein

530 aminoacids, 55,6 kDa

>Rv2846c MTALNDTERAVRNWTAGRPHRPAPMRPPRSEETASERPSRYYPTWLPSRSFIAAVIAIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWVITAYVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEATLVIARLSQGVGSAIASPTGLALVATTFPKGPARNAATAVFAAMTAIGSVMGLVVGGALTEVSWRWAFLVNVPIGLVMIYLARTALRETNKERMKLDATGAILATLACTAAVFAFSIGPEKGWMSGITIGSGLVALAAAVAFVIVERTAENPVVPFHLFRDRNRLVTFSAILLAGGVMFSLTVCIGLYVQDILGYSALRAGVGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGYLLFGAMLYGSFFMHRGVPYFPNLVMPIVVGGIGIGMAVVPLTLSAIAGVGFDQIGPVSAIALMLQSLGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDVQLAALDHAYTYGLLWVAGAAIIVGGMALFIGYTPQQVAHAQEVKEAIDAGEL*

Pedant links: Pedant report, prosite patterns,
intragenome comparison,
blastp homologues

Lookup

PubMed: efpA, efpA and M. tuberculosis,
putative efflux protein,
Sanger Rv2846c, Tigr MT2912

Rv2847c

1215 bp reverse orf at [08:34]

-> Mtbook page 974

cysG2

multifunctional enzyme, siroheme synthase

Function

Classification I. D.3
Category I. Small-molecule metabolism
Class D. Amino acid biosynthesis
Group 3. Serine family

Protein

405 aminoacids, 41,9 kDa

>Rv2847c VTENPYLVGLRLAGKKVVVVGGGTVAQRRLPLLIASGADVHVIAPSVTPAVEAMDQITLSVRDYRDGDLDGAWYAIAATDDARVNVAVVAEAERRRIFCVRADIAVEGTAVTPASFSYAGLSVGVLAGGEHRRSAAIRSAIREALQQGVITAQSSDVLSGGVALVGGGPGDPELITVRGRRLLAQADVVVADRLAPPELLAELPPHVEVIDAAKIPYGRAMAQDAINAVLIERARSGNFVVRLKGGDPFVFARGYEEVLACAHAGIPVTVVPGVTSAIAVPAMAGVPVTHRAMTHEFVVVSGHLAPGHPESLVNWDALAALTGTIVLLMAVERIELFVDVLLKGGRTADTPVLVVQHGTTAAQQTLRATLADTPEKVRAAGIRPPAIIVIGAVVGLSGVRGLNNS*

Pedant links: Pedant report, prosite patterns,
intragenome comparison,
blastp homologues

Lookup

PubMed: cysG2, cysG2 and M. tuberculosis,
multifunctional enzyme, siroheme synthase,
Sanger Rv2847c, Tigr MT2913

Rv2848c

1371 bp reverse orf at [08:35]

-> Mtbook page 975

cobB

cobyrinic acid a,c-diamide synthase

Function

Classification I. G.13
Category I. Small-molecule metabolism
Class G. Biosynthesis of cofactors, prosthetic groups and carriers
Group 13. Cobalamin

Protein

457 aminoacids, 47 kDa

>Rv2848c MRVSAVAVAAPASGSGKTTIATGLIGALRQAGHTVAPFKVGPDFIDPGYHALAAGRPGRNLDPVLVGERLIGPLYAHGVAGADIAVIEGVLGLFDGRIGPAGGAPAAGSTAHVAALLGAPVILVVDARGQSHSVAALLHGFSTFDTATRIAGVILNRVGSARHEQVLRQACDQAGVAVLGAIPRTAELELPTRYLGLVTAVEYGRRARLAVQAMTAVVARHVDLAAVIACAGSQAAHPPWDPVIAVGNTARQPATVAIAAGRAFTFGYAEHAEMLRAAGAEVVEFDPLSETLPEGTDAVVLPGGFPEQFTAELSANDTVRRQINELAAAGAPVHAECAGLLYLVSELDGHPMCGVVAGSARFTQHLKLGYRDAVAVVDSALYSVGERVVGHEFHRTAVTFADSYQPAWVYQGQDVDDVRDGAVHSGVHASYLHTHPAATPGAVARFVAHAACNTPRA*

Pedant links: Pedant report, prosite patterns,
intragenome comparison,
blastp homologues

Lookup

PubMed: cobB, cobB and M. tuberculosis,
cobyrinic acid a,c-diamide synthase,
Sanger Rv2848c, Tigr MT2914

Rv2850c

1887 bp reverse orf at [08:35]

-> Mtbook page 975

possible magnesium-chelatase

Function

Classification IV. K
Category IV. Other
Class K. Chelatases (2)

Protein

629 aminoacids, 67 kDa

>Rv2850c VKPYPFSAIVGHDRLRLALLLCAVRPEIGGALIRGEKGTAKSTAVRGLAALLSVATGSTETGLVELPLGATEDRVVGSLDLQRVMRDGEHAFSPGLLARAHGGVLYVDEVNLLHDHLVDILLDAAAMGRVHVERDGISHSHEARFVLIGTMNPEEGELRPQLLDRFGLTVDVQASRDIDVRVQVIRRRMAYEADPDAFVARYADADAELAHRIAAARATVDDVVLGDNELRRIAALCAAFDVDGMRADLVVARTAAAHAAWRGVRTVEEQDIRAAAELALPHRRRRDPFDDHGIDRDQLDEALALASVDPEPEPDPPGGGQSANEPASQPNSRSKSTEPGAPSSMGDDPPRPASPRLRSSPRPSAPPSKIFRTRALRVPGVGTGAPGRRSRARNASGSVVAAAEVSDPDAHGLHLFATLLAAGERAFGAGPLRPWPDDVRRAIREGREGNLVIFVVDASGSMAARDRMAAVSGATLSLLRDAYQRRDKVAVITFRQHEATLLLSPTSSAHIAGRRLARFSTGGKTPLAEGLLAARALIIREKVRDRARRPLVVVLTDGRATAGPDPLGRSRTAAAGLVAEGAAAVVVDCETSYVRLGLAAQLARQLGAPVVRLEQLHADYLVHAVRGVA*

Pedant links: Pedant report, prosite patterns,
intragenome comparison,
blastp homologues

Lookup

possible magnesium-chelatase,
Sanger Rv2850c, Tigr MT2916

Rv2853

1845 bp forward orf at [08:36]

-> Mtbook page 977

PE_PGRS

Function

Classification IV. C.1.b
Category IV. Other
Class C. PE and PPE families
Group 1. PE family
Subgroup b

Protein

615 aminoacids, 51,3 kDa

>Rv2853 MLYVVASPDLMTAAATNLAEIGSAISTANGAAALPTVEVVAAAADEVSTQIAALFGAHARSYQTLSTQAAAFHSRFVQALTTAAASYASVEAANASPLQVALDVINAPAQTLLGRPLIGNGADGSTPGQAGGPGGLLYGNGGNGAAGGPNQAGGAGGNAGLIGNGGAGGAGGVGAVGGKRGTGGLLFGNGGAGGQGGLGLAGINGGSGGQGGHGGNAILFGQGGAGGPGGTGAMGVAGTNPTPIGTAAPGSDGVNQIGNGGNTDLTGGAGGDGNAGSTTVNGGNGGTGGAARNSSGGTGNSFGGAGGAGGDGANGGDGGAGGEALTEGGATAVSGAGGKGGNAEASGGAGGNGGKGGFAQATTSVTGGNGGNGGNGHDSNAPGGAGGSGGVGGDGGRGGLLAGNGGTGGAGGNGGTGGAGAPGGAGGAGGKADIANSLGDNATVTGGNGGTGGDGGSALGTGGAGGAGGLGGHGGAGGLLIGNGGAGGAGGLGGAGGAGGAGGEGGAGGAGGEAIPGGASTNSAGGDGGAGGTGGNGGDGGAGGAPGLGGAGGAGGWLIGQSGSTGGGGAGGAGGAGGAGGAGGSGGAGGHGDTTSGKNGSSGTAGFDGNPGQPG*

Pedant links: Pedant report, prosite patterns,
intragenome comparison,
blastp homologues

Lookup

PubMed: PE_PGRS, PE_PGRS and M. tuberculosis,
Sanger Rv2853, Tigr MT2920

Rv2855

1377 bp forward orf at [08:36]

-> Mtbook page 977

gorA

glutathione reductase homologue

Function

Classification I. G.10
Category I. Small-molecule metabolism
Class G. Biosynthesis of cofactors, prosthetic groups and carriers
Group 10. Thioredoxin, glutaredoxin and mycothiol

Protein

459 aminoacids, 49,9 kDa

>Rv2855 METYDIAIIGTGSGNSILDERYASKRAAICEQGTFGGTCLNVGCIPTKMFVYAAEVAKTIRGASRYGIDAHIDRVRWDDVVSRVFGRIDPIALSGEDYRRCAPNIDVYRTHTRFGPVQADGRYLLRTDAGEEFTAEQVVIAAGSRPVIPPAILASGVDYHTSDTVMRIAELPEHIVIVGSGFIAAEFAHVFSALGVRVTLVIRGSCLLRHCDDTICERFTRIASTKWELRTHRNVVDGQQRGSGVALRLDDGCTINADLLLVATGRVSNADLLDAEQAGVDVEDGRVIVDEYQRTSARGVFALGDVSSPYLLKHVANHEARVVQHNLLCDWEDTQSMIVTDHRYVPAAVFTDPQIAAVGLTENQAVAKGLDISVKIQDYGDVAYGWAMEDTSGIVKLITERGSGRLLGAHIMGYQASSLIQPLIQAMSFGLTAAEMARGQYWIHPALPEVVENALLGLR*

Pedant links: Pedant report, prosite patterns,
intragenome comparison,
blastp homologues

Lookup

PubMed: gorA, gorA and M. tuberculosis,
glutathione reductase homologue,
Sanger Rv2855, Tigr MT2922

Rv2856

1116 bp forward orf at [08:36]

-> Mtbook page 978

nicT

probable nickel transport protein

Function

Classification III. A.2
Category III. Cell processes
Class A. Transport/binding proteins
Group 2. Cations

Protein

372 aminoacids, 40,5 kDa

>Rv2856 MASSQLDRQRSRSAKMNRALTAAEWWRLGLMFAVIVALHLVGWLTVTLLVEPARLSLGGKAFGIGVGLTAYTLGLRHAFDADHIAAIDNTTRKLMSDGHRPLAVGFFFSLGHSTVVFGLAVMLVTGLKAIVGPVENDSSTLHHYTGLIGTSISGAFLYLIGILNVIVLVGIVRVFAHLRRGDYDEAELEQQLDNRGLLIRFLGRFTKSLTKSWHMYPVGFLFGLGFDTATEIALLVLAGTSAAAGLPWYAILCLPVLFAAGMCLLDTIDGSFMNFAYGWAFSSPVRKIYYNITVTGLSVAVALLIGSVELLGLIANQLGWQGPFWDWLGGLDLNTVGFVVVAMFALTWAIALLVWHYGRVEERWTPAPDRTT*

Pedant links: Pedant report, prosite patterns,
intragenome comparison,
blastp homologues

Lookup

PubMed: nicT, nicT and M. tuberculosis,
probable nickel transport protein,
Sanger Rv2856, Tigr MT2923

Rv2858c

1365 bp reverse orf at [08:37]

-> Mtbook page 979

aldC

aldehyde dehydrogenase phenylacetaldehyde

Function

Classification I. B.7
Category I. Small-molecule metabolism
Class B. Energy metabolism
Group 7. Miscellaneous oxidoreductases and oxygenases 171

Protein

455 aminoacids, 48,3 kDa

>Rv2858c MSTTQLINPATEEVLASVDHTDANAVDDAVQRARAAQRRWARLAPAQRAAGLRAFAAAVQAHLDELAALEVANSGHPIVSAEWEAGHVRDVLAFYAASPERLSGRQIPVAGGVDVTFNEPMGVVGVITPWNFPMVIASWAIAPALAAGNAVLVKPAELTPLTTMRLGELAVEAGLDEDLLQVLPGKGTVVGERFVTHPDIRKIVFTGSTEVGKRVMAGAAAQVKRVTLELGGKSANIVFHDCDLERAATTAPAGVFDNAGQDCCARSRILVQRSVYDRFMELLEPAVHSIVVGDPGSRATEMGPLVSRAHRDKVAGYVPDDAPVAFRGTAPAGRGFWFPPTVLTPKRGDRTVTDEIFGPVVVVLTFDDEADAISLANDTAYGLSGSIWTDDLSRALRVARAVESGNLSVNSHSSVRFNTPFGGFKQSGVGRELGPDAPLQFTETKNVFIAVGEEM*

Pedant links: Pedant report, prosite patterns,
intragenome comparison,
blastp homologues

Lookup

PubMed: aldC, aldC and M. tuberculosis,
aldehyde dehydrogenase phenylacetaldehyde ,
Sanger Rv2858c, Tigr MT2926

Rv2860c

1371 bp reverse orf at [08:37]

-> Mtbook page 979

glnA4

proable glutamine synthase

Function

Classification I. D.1
Category I. Small-molecule metabolism
Class D. Amino acid biosynthesis
Group 1. Glutamate family

Protein

457 aminoacids, 49,7 kDa

>Rv2860c VTGPGSPPLAWTELERLVAAGDVDTVIVAFTDMQGRLAGKRISGRHFVDDIATRGVECCSYLLAVDVDLNTVPGYAMASWDTGYGDMVMTPDLSTLRLIPWLPGTALVIADLVWADGSEVAVSPRSILRRQLDRLKARGLVADVATELEFIVFDQPYRQAWASGYRGLTPASDYNIDYAILASSRMEPLLRDIRLGMAGAGLRFEAVKGECNMGQQEIGFRYDEALVTCDNHAIYKNGAKEIADQHGKSLTFMAKYDEREGNSCHIHVSLRGTDGSAVFADSNGPHGMSSMFRSFVAGQLATLREFTLCYAPTINSYKRFADSSFAPTALAWGLDNRTCALRVVGHGQNIRVECRVPGGDVNQYLAVAALIAGGLYGIERGLQLPEPCVGNAYQGADVERLPVTLADAAVLFEDSALVREAFGEDVVAHYLNNARVELAAFNAAVTDWERIRGFERL*

Pedant links: Pedant report, prosite patterns,
intragenome comparison,
blastp homologues

Lookup

PubMed: glnA4, glnA4 and M. tuberculosis,
proable glutamine synthase,
Sanger Rv2860c, Tigr MT2928

rbfA

ribosome-binding factor A

infB

initiation factor IF-2

nusA

transcription termination factor

proS

prolyl-tRNA synthase

efpA

putative efflux protein

cysG2

multifunctional enzyme, siroheme synthase

cobB

cobyrinic acid a,c-diamide synthase

cobA

cob(I)alamin adenosyltransferase

possible magnesium-chelatase

PE_PGRS

gorA

glutathione reductase homologue

nicT

probable nickel transport protein

putative dehydrogenase

aldC

aldehyde dehydrogenase phenylacetaldehyde

glnA4

proable glutamine synthase

map

methionine aminopeptidase